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Latest research news
Pilot research in dogs indicates large clinical trial needed
March 2009
In collaboration with Bristol University Veterinary School, the British Homeopathic Association has recently published the pilot findings of a research initiative studying atopic dermatitis in dogs. We are now designing a multi-centre clinical trial, and we would be pleased to hear from potential collaborators at any of the UK’s vet schools, specialist referral centres or local veterinary hospitals.
New evidence in favour of homeopathy
November 2008
Two newly published studies1,2 show that the conclusions of a review published in The Lancet about the effectiveness of homeopathy3 were seriously flawed.
The review, which appeared in 2005, started with 110 placebo-controlled clinical trials of homeopathy matched with 110 of conventional medicine. Twenty-one homeopathy trials and 9 conventional medicine trials were of “higher quality”. From that smaller set of trials, the authors then focused their attention on respectively 8 and 6 “large trials of higher quality” in several different medical conditions. Based on these 14 studies, the review concluded that there was “weak evidence for a specific effect of homoeopathic remedies, but strong evidence for specific effects of conventional interventions”. The review was criticised at the time for its opacity, as it gave no indication of which trials were analysed nor the various assumptions made about the data. Sufficient detail to enable a reconstruction of the analysis was eventually published by the authors.
The new studies, which reconstruct the review’s analysis, cast severe doubts on its negative conclusions, showing that it was based on a series of hidden judgments unfavourable to homeopathy. A positive conclusion for homeopathy is in fact obtained if all 21 “higher quality” trials are included in the analysis. If fewer than 21 trials are analysed, a positive or negative conclusion for homeopathy is crucially dependent on the exact number of trials selected. A firm positive conclusion is found, for example, merely by omitting four trials that showed Arnica is ineffective for muscle soreness after long-distance running.
Whether the conclusions of the analysis are positive or negative is therefore highly sensitive to the choice of which “higher quality” trials are included. The clear implication is that homeopathy for certain conditions is not placebo.
References:
1. Lüdtke R, Rutten ALB. The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. J Clin Epidemiol, Oct 2008. http://dx.doi.org/10.1016/j.jclinepi.2008.06.015
2. Rutten ALB, Stolper CF. The 2005 meta-analysis of homeopathy: the importance of post-publication data. Homeopathy, Oct 2008. http://dx.doi.org/10.1016/j.homp.2008.09.008
3. Shang A, Huwiler-Müntener K, Nartey L, et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet 2005; 366: 726–732.